Working to facilitate rapid translation of scientific discoveries into therapeutics

Ke Ning

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Ke Ning, MD, PhD

Ke Ning graduated in Medicine from First Military Medical University (Southern Medical University) in China in 1985. He undertook his Specialist Training in Neurosurgery at Sun Yatsen University of Medical Science in China and got a M.Sc in Neurosurgery in 1991. Ke obtained his PhD in neuroscience at the Third Military Medical University in China in 1996 and was promoted to an associate professor in neurosurgery at Southern Medical University in China in 1997. Since 1999, Ke has undertaken full time research in neuroscience in the USA, Canada and the UK. He joined the University of Sheffield as a Lecturer in Translational neuroscience in 2006 and was promoted to a Senior Lecturer in Translational neuroscience in 2011. He has been closely involved in translational neuroscience research and teaching in motor neuron diseases. The focus of his research is the use of viral vector-mediated gene therapy and stem cell strategies to treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). His research discoveries have included evidence that depression of PTEN increases neuronal survival and that a novel leptin signalling pathway is activated by PTEN inhibition; proof-of-concept of regulation of huntingtin aggregation by Arfaptin 2 and evidence for circadian regulation of GABAA by CKI in the rat suprachiasmatic nuclei.

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