EUSTM-2015

3rd Annual Congress of The European Society for Translational Medicine

Vienna, Austria, 1-4 September, 2015

EUSTM 2015 – SCIENTIFIC AGENDA

09:00

31 August, 2015 Pre Conference workshop

DAY1

Tuesday, 01 September 2015

08:00 Conference Registration
09:45 Welcome Remarks

Gottfried Köhler, Austrian Society for Translational Medicine (ASTM)

Aamir Shahzad, President, European Society for Translational Medicine (EUSTM)

Randal J Cohrs, Vice, President, European Society for Translational Medicine (EUSTM)

10:15 Keynote Talk
Angiogenesis and the tumor microenvironment as targets for cancer prevention
Adriana Albini, Scientific Director Fondazione Multimedica ONLUS, Milan, Italy
11:00 Scientific Session A: New Horizons in Biomarkers and Novel Diagnostics
(Organized by EUSTM Expert Panel on Biomarkers and Novel 
Diagnostics)

Chair : Thomas J. Goodwin, Member, EUSTM Advisory Board, Houston, USA.

Towards an integral diagnostic system for acute kidney injury
Francisco J. Lopez-Hernandez, University Hospital of Salamanca, IBSAL, Salamanca, Spain.

Development of Translatable Region-Specific Molecular Signatures for Sub-Acute Drug Induced Kidney Injury
Sara Snelling, University of Leeds, Leeds, UK

Advanced Light Microscopy: Recent Developments and Applicative Potential for Translational Medicine
Josef Gotzmann, Max F. Perutz Laboratories; Head of Central Facility BioOptics/ Light Microscopy, Vienna, Austria

12:00 Lunch I Exhibition
13:00 Scientific Session B: Novel Findings and Updates in Omics Sciences and applications in Oncology
(Organised by EUSTM Expert Panel on Omics Applications)

Chair : Martine J. Jager, Head, Laboratory of Ophthalmology, Leiden University, The Netherlands.

Therapeutic exploitation of the cancer glycome; a drug discovery study of the therapeutic potential of the glycan-binding protein galectin-9 for colorectal k-Ras mutant cancer
Edwin Bremer, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.

Beyond the sarcoma genome complexity
Frédéric Chibon, ​INSERM U916 – Institut Bergonié, Bordeaux, France.

Correlation between Genetic modifications and inflammation in Uveal Melanoma
Martine J. Jager, Head, Laboratory of Ophthalmology, Leiden University, The Netherlands.

14:00 Scientific Session C: Translating Novel Pathophysiological Findings into Therapeutic Developments (Organised by EUSTM Expert Panel on Oncology)

Chair : Zhaohua Zhong, Deputy Dean, Department of Microbiology, HMU, Harbin, China.

CT-1 regulates renal fibrosis induced by obstructive nephropathy
Carlos Martinez Salgado, Instituto de Estudios de Ciencias de la Salud de Castilla y León (IECSCYL), Salamanca, Spain.

Autophagy-dependent regulation of tubule formation in the brain endothelial cell line bEND.5
Mauro Cataldi, Department of Neuroscience, Federico II University of Naples, Napoli, Italy.

The Role of miR-122 in the Hepatocellular carcinogenesis
Zhaohua Zhong, Deputy Dean, Department of Microbiology, Harbin Medical University, Harbin, China.

 15:00 Scientific Session D: Novel Findings and Updates in Omics Sciences II
(Organised by EUSTM Expert Panel on Omics Applications)

Chair : Randal J Cohrs, Vice, President, European Society for Translational Medicine (EUSTM).

Human Serum Metabolome in Health and Disease: The Human Serum Metabolome Project‏
Roy Goodacre, School of Chemistry, The University of Manchester, Manchester, UK.

Oxidative Stress in Hostile Environments: A Translational Omics-Based Approach to Personalized Assessment & Countermeasures Development
Michael A. Schmidt, Colorado State University, Colorado, USA

 16:00 Coffee Break I Poster Viewing and Exhibition
 16:30 Scientific Session E: Novel Findings and Updates in Data Mining & Management
(Organised by EUSTM Expert Panel on Data Mining & Management)

Chair : Antonio Facchiano, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy.

Big Data mining for the hospital patients of cardiovascular diseases
Kunlun He, Department of Translational Medicine, Chinese PLA General Hospital, Beijing, China.

Analyzing large data-sets. How to organize large sample data-sets and to retrive additional information
Antonio Facchiano, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy.

 17:30 Scientific Session F: Novel Pathophysiological Findings
(Organised by EUSTM Expert Panel on Medical Affairs and Personalized Medicine)

Chair : Shahzada A., Medical University of Vienna, Vienna, Austria.

OTR antagonist, OBE001, suppresses OT-mediated inflammatory responses in human gestational tissues
Vasso Terzidou, ObsEva SA, Geneva, Switzerland.

Increased tissue load of FeO3-containing PLGA-NPs coupled with anti Coll IV antibodies in normal and metastatic liver by focused microwave-induced hyperthermia
Chiara Castellani, Dept. of Cardiac, Thoracic and Vascular Sciences, University of Padua, Italy

Role of bile extracellular vesicles in differentiating malignant from nonmalignant biliary stenosis
Valeria Severino, Department of Internal Medicine Specialties, Geneva University, Geneva, Switzerland

 18:30  Day End

DAY 2

Wednesday, 02 September 2015

08:00 Conference Registration
09:00 Introduction
Aamir Shahzad, President, European Society for Translational, Medicine (EUSTM)
09:15 Keynote Talk
Susceptibility to breast cancer: from genetics to prevention
Ulrich Pfeffer, Head, Functional Genomics lab, National Institute for Cancer Research, IST, Genova, Italy
10:00 Coffee Break I Exhibition
10:30 Satellite Symposium: New Horizons in Data Mining & Management
(Organised by EUSTM Expert Panel on Data Mining & Management)

Chair : Puthen Veettil Jithesh, Sidra Medical and Research Center, Doha, Qatar.

Talks:

Bridging the Gap between Translational Research and Precision Medicine Clinical Workflow
Wanmei ou, Oracle Health Sciences, Burlington, MA, USA.

Experiences and challenges in running a Bioinformatics Core facility
Puthen Veettil Jithesh, Sidra Medical and Research Center, Doha, Qatar

Discussion Panel:

Antonio Facchiano
Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy.

Wanmei ou
Oracle Health Sciences, Burlington, MA, USA.

Puthen Veettil Jithesh
Sidra Medical and Research Center, Doha, Qatar

12:00 Lunch
 13:00 Scientific Session A: New Horizons in Disease Modeling
(Organised by EUSTM Expert Panel on Disease Modeling)

Chair : Matthias Nees, Turku Centre for Biotechnology, Turku, Finland.

Animal Models Characterization: From the Bench to the Bedside
Elizabeth K. Leffel, Leffel Consulting Group, LLC, Terapio, Austin, Texas, USA.

Prenatal exposure to Trichostatin A: epigenetic factors and animal models of autism
Tomasz Schneider, Durham University School of Medicine, Pharmacy & Health, Stockton-on-Tees, United Kingdom

Complex Tissue Models that Mimic the Tumour Microenvironment, Heterogeneity, Invasion, Drug Sensitivity and Progression of Cancers
Matthias Nees, Turku Centre for Biotechnology, Turku, Finland

 14:00 Scientific Session B: Translating Novel Pathophysiological Findings into Therapeutic Developments
(Organised by EUSTM Expert Panels)

Chair : Elizabeth K. Leffel, Leffel Consulting Group, LLC, Terapio, Austin, Texas, USA.

Development of tailored antimicrobial treatment regimens and novel host- pathogen insights for respiratory tract infections and sepsis. (TAILORED-Treatment)
John P. Hays, Erasmus University Medical Centre, Rotterdam, The Netherlands

Stromal exosomes convey increased proliferation and chemoresistance to colorectal cancer cells via ERK and AKT activation respectively
Rahul Bhome, Cancer Sciences, Southampton University, Southampton General Hospital, Southampton, UK

Deregulated stromal and epithelial microRNAs: Role in predicting recurrence in Stage II colorectal cancer
Alex Mirnezami, University of Southampton Cancer Sciences Division, Southampton, UK

 15:00 Scientific Session C: New Horizons in Structural & Computational Biology

Chair : Kristina Djinovic-Carugo, Max F. Perutz Laboratories, University of Vienna, Austria.

Translational Bioinformatics in action: Re-defining the Current Diseases Taxonomy
Erfan Younesi, Department of Bioinformatics, Fraunhofer Institute SCAI, Germany.

Structural Basis for the Neutralization Mechanism of Hepatitis E Virus by Monoclonal Antibodies
J Sivaraman, Department of Biological Sciences, National University of Singapore, Singapore

Structural basis of myofibrillar myopathies caused by selected filamin mutations
Kristina Djinovic-Carugo, Head, Department for Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Austria

16:00 Coffee Break I Poster Viewing and Exhibition
 16:30 Scientific Session D: New horizons in Regenerative Medicine & Stem Cells Research

Chair : Marianna Bei, Harvard Medical School & Massachusetts General Hospital,Boston, USA.

Identification of a New Cell Population Endowed with a Healing Capacity and Constitutively Circulating in Healthy Conditions
Roberta Tasso, Laboratory of Regenerative Medicine DIMES, University of Genova & A.O.U. San Martino-IST, Genova, Italy

Identification of genes specifically expressed in Stem Cells using an unbiased data-driven approach
Frank Staubli, Nebion AG, Zurich, Switzerland

Kcnh2 and Kcnj8 Interactively Regulate Skin Wound Healing and Regeneration
Marianna Bei, Harvard Medical School & Massachusetts General Hospital, Shriners Burns Hospital, Boston, USA

 17:30 Scientific Session E: New Horizons in Biomarkers and Novel Diagnostics
(Organised by EUSTM Expert Panel on Biomarkers and Novel Diagnostics)

Chair : Gottfried Köhler, CEO, OnkoTec, Austria.

Molecular biomarkers in neurosciences: two-way translational strategies supporting drug development and early disease detection
André Nogueira da Costa, Department of Non-Clinical Development, UCB BioPharma SPRL, Belgium

In vivo/in vitro translation of a molecular signature in the context of preclinical drug-induced kidney injury
Caroline Berteau, Faculty of Pharmacy, University of Lorraine, Nancy, France

Development of a decision-making biomarker for CRTH2 antagonism in clinical studies
Daniel Strasser, Actelion Pharmaceuticals Ltd, Switzerland

 18:30  Day End

DAY 3

Thursday, 03 September 2015

08:30 Conference Registration
09:00 Special Scientific Session: New horizons in Preventive Medicine & Space Flight Omics
(Organised by EUSTM Expert Panels on Omics Applications, Medical Affairs & Public Health)

Chair : Araz A. Raoof, Vice President, Global Functional Head C.R.E.A.Te, Janssen Pharamecutica, Belgium.

The challenges and opportunities for diabetes preventative services in family medicine
Josie Messina & Rebecca Morris, University of Manchester, Centre for Primary Care, Williamson Building, Manchester, UK

Space Flight Omics and their Relation to Translational Medicine on Earth
Michael A. Schmidt, Co-chair, Infectious Disease Research Complex, Colorado State University, Colorado, USA

The role of biomedical technologies in modern drug discovery and early clinical development
Araz A. Raoof, Vice President, Global Functional Head C.R.E.A.Te, Janssen Pharamecutica, Belgium.

10:00 Coffee Break I Exhibition
10:30 Panel Discussion: New Horizons in drug discovery & development (Organised by EUSTM Joint Expert Panels)

Chair : Laurent Audoly, Senior Vice President R&D, Global Head of Drug Development and Translational Medicine, France.

Araz Raoof
Vice President, Global Functional Head C.R.E.A.Te Johnson & Johnson, Antwerp, Belgium.

Daniel Strasser
Senior Lab Head, Translational Science Drug Discovery Biology, Actelion Pharmaceuticals Ltd,  Switzerland

André Nogueira da Costa
Department of Non-Clinical Development, UCB BioPharma SPRL, Belgium.

Laurent Audoly
Senior Vice President R&D, Global Head of Drug Development and Translational Medicine, France.

12:00 Lunch
 13:00 Scientific Session A: Novel Findings and Updates in Omics Sciences & applications in oncology
(Organised by EUSTM Expert Panel on Omics Applications)

Chair : Beatrice Bachmeier, Ludwig-Maximilians-University, Munich, Germany.

Specific PIWI-interacting RNA (piRNA) expression patterns in human cancer
Alessandro Weisz, Lab. Mol. Medicine and Genomics, University of Salerno, Salerno, Italy

Epigenetic regulation of gene transcription and cell cycle progression by Ikaros in high-risk leukemia
Sinisa Dovat, Director, Translational Research, Pennsylvania State University, College of Medicine, Pennsylvania, USA

miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via downregulation of the inflammatory cytokines CXCL1 and -2
Beatrice Bachmeier, Inst. of Laboratory Medicine, Ludwig-Maximilians-University, Munich, Germany

 14:00 Panel Discussion: New Horizons in Personalized Medicine
(Organised by EUSTM Joint Expert Panels)

Chair : Aamir Shahzad, President, European Society for Translational Medicine (EUSTM).

Ulrich Pfeffer
Head, Functional Genomics lab, National Institute for Cancer Research, IST, Genova, Italy

Erfan Younesi
Fraunhofer Institute for Algorithms & Scientific Computing SCAI, Sankt Augustin, Germany

Alexandre Passioukov
Vice President, Translational Medicine, Pierre Fabre, Toulouse, France

 15:30
Final Remarks

Aamir Shahzad
President, European Society for Translational Medicine (EUSTM)

Randal J Cohrs
Vice President, European Society for Translational Medicine (EUSTM)

 16:00  End of Conference
09:00

4th September, GTMC Consortium Meeting

16:00

4th September, 2015 PCTM Exam

2013-2017©European Society for Translational Medicine (EUSTM)